- Steven Strait as Jim Holden
- Cas Anvar as Alex Kamal
- Dominique Tipper as Naomi Nagata
- Wes Chatham as Amos Burton
- Florence Faivre as Julie Mao
- Shawn Doyle as Sadavir Errinwright
- Shohreh Aghdashloo as Chrisjen Avasarala
Guest Starring Edit
- Chad L. Coleman as Fred Johnson
- Nick E. Tarabay as Cotyar
- Elias Toufexis as the Human-Protomolecule Hybrid
- Jonathan Whittaker as Esteban Sorrento-Gillis
- This episode marks the beginning of the book Caliban's War.
- The Ganymede incident will take place during this episode.
- This episode marks the introduction of Mei Meng and her father, Praxidike Meng.